Calvin Miller was born in Enid, Oklahoma. He graduated from Enid High School and attended Oklahoma Baptist University, graduating with a B.S. degree in 1958. He attended Midwestern Baptist Theological Seminary in Kansas City, graduating with a Master of Divinity degree in 1961 and a Doctor of Ministry degree in 1975. In 1959 he was married to Barbara Joyce Harman. They had two children: Melanie, born February 22, 1962 and Timothy, born July 30, 1963.

His first full-time pastorate was Plattsmouth Baptist Church, Plattsmouth, Nebraska, 1961-1966.  He founded Westside Church in Omaha, Nebraska, in January of 1966, where he served as senior pastor for 25 years. During his pastorate the congregation grew from 10 members to more than 2,500 members.  From 1991-1998, Miller served as Professor of Communication and Ministry Studies and Writer-in-Residence at Southwestern Baptist Theological Seminary, Ft. Worth, Texas. In January 1999, he joined the faculty of Samford University's Beeson Divinity School in Birmingham, Alabama.

He was the author of more than forty books of popular theology and inspiration. His poems and free-lance articles have appeared in various journals and magazines such as Christianity Today, Campus Life, Leadership, and His. He served as an inspirational speaker in various assemblies and religious convocations, both in his own denomination and other Christian gatherings. Dr. Miller believed in the primacy of evangelism for the church in every age. In his own church ministry he sought to be both a contemporary apologist, helping the church provide answers for a secular culture, and the equipper of the contemporary church for the task of missions and evangelism.

Calvin Miller passed on to be with his Lord on August 19, 2012 at 12:30 CDT. He spent a great deal of his life writing love letters to his Lord Jesus. He is now with him.